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| Nephrotic Syndrome (NS) is a clinical condition resulting from the loss of large amounts of protein from the blood into the urine. Usually, the amount of proteinuria is sufficient to cause hypoproteinemia and consequent edema. This hypoalbuminemia is associated with decreases in effective renal perfusion and an increase in tubular reabsorption of salt and water. |
| Thus, in a manner analogous to that of congestive heart failure, the kidney continues to maximize its reabsorption of salt and water in a physiologic setting in which total body fluid is increased. |
| The NS may be a feature of any form of childhood GN or may be secondary to other systemic diseases, nephrotoxins, or allergic reactions. |
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