Journal Club

Lipids

Overview:

High-risk pediatric patients include:

-- Transplant recipients

-- SLE

-- Nephrotic syndrome

-- CRI

Narrative vs Systematic Review

Systematic Review Summary

Evaluating Systematic Reviews:

Question 1: Can you find an important clinical question which the review addressed?

Question 2: Was a thorough search done of the appropriate databases and were other potentially important sources explored?

Question 3: Was methodological quality assessed and the trials weighted accordingly?

Question 4: How sensitive are the results to the way the review has been done?

Question 5: Have the numerical results been interpreted with common sense and due regard to the broader aspects of the problem?

BMJ No 7109 Volume 315

Algorithm for management

Thrombosis Research (2006) 118, 49—58

Mechanism of action of statins

Statins approved for children

Risk factors for CVE

Pediatrics 2007;119;370-380

LINK to AHA Statement and Guideline Development site

Links:

Drug therapy of high-risk lipid abnormalities in children and adolescents

Hyperlipidemia in children

The use of statins in pediatrics - knowledge base, limitations, and future directions

Prospective monitoring of lipid profiles in children receiving pravastatin preemptively after renal transplantation

Lipoprotein metabolism in chronic renal insufficiency

Linkto Virtual Library of articles on all aspects of Evidence Based Practice